[1] LANGER R. Drug delivery and targeting[J]. Nature, 1998, 392(6679):5-10.
[2] RAEMDONCK K, BRAECKMANS K, DEMEESTER J, et al. Merging the best of both worlds:hybrid lipid-enveloped matrix nanocomposites in drug delivery[J]. Chem Soc Rev, 2014, 43(1):444-472.
[3] HUBBELL J A, CHILKOTI A. Nanomaterials for drug delivery[J]. Science, 2012, 337(6092):303-305.
[4] MURA S, NICOLAS J, COUVREUR P. Stimuli-responsive nanocarriers for drug delivery[J]. Nat Mater, 2013, 12(11):991-1003.
[5] CHEN C, WANG J, ZHAO E, et al. Self-assembly cationic nanoparticles based on cholesterol-grafted bioreducible poly(amidoamine) for siRNA delivery[J]. Biomaterials, 2013, 34(21):5303-5316.
[6] LEPELTIER E, BOURGAUX C, COUVREUR P. Nanoprecipitation and the "Ouzo effect": application to drug delivery devices[J]. Adv Drug Deliv Rev, 2014, 71:86-97.
[7] ZHANG Y, CHAN H F, LEONG K W. Advanced materials and processing for drug delivery: the past and the future[J]. Adv Drug Deliv Rev, 2013, 65(1):104-120.
[8] DESAI N. Challenges in development of nanoparticle-based therapeutics[J]. AAPS J, 2012, 14(2):282-295.
[9] GAUMET M, VARGAS A, GURNY R, et al. Nanoparticles for drug delivery:the need for precision in reporting particle size parameters[J]. Eur J Pharm Biopharm, 2008, 69(1):1-9.
[10] MENGYUAN G, FENGHUA L, YU B. Application of microfluidic technology in synthesisof nanoparticles[J]. Chin J Appl Chem(应用化学), 2016(33):1115-1125.
[11] WHITESIDES G M. The origins and the future of microfluidics[J]. Nature, 2006, 442(7101):368-373.
[12] MANZ A, HARRISON D J, VERPOORTE E, et al. Planar chips technology for miniaturization and integration of separation techniques into monitoring systems-capillary electrophoresis on a chip[J]. J Chromatogr, 1992, 593(1-2):253-258.
[13] MANZ A, HARRISON D J, VERPOORTE E, et al. Minialurization of chemical analysis system-a look into next century's technology or just a fashionable craze[J]. Chimia, 1991, 45(4):103-105.
[14] MANZ A, GRABER N, WIDMER H M. Miniaturized total chemical-analysis systems-a novel concept for chemical sensing[J]. Sensor Actuat B-Chem, 1990, 1(1-6):244-248.
[15] DITTRICH P S, MANZ A. Lab-on-a-chip: microfluidics in drug discovery[J]. Nat Rev Drug Discov, 2006, 5(3):210-218.
[16] DEMELLO A J. Control and detection of chemical reactions in microfluidic systems[J]. Nature, 2006, 442(7101):394-402.
[17] SACKMANN E K, FULTON A L, BEEBE D J. The present and future role of microfluidics in biomedical research[J]. Nature, 2014, 507(7491):181-189.
[18] AHN J, KO J, LEE S, et al. Microfluidics in nanoparticle drug delivery; from synthesis to pre-clinical screening[J]. Adv Drug Deliv Rev, 2018, 128:29-53.
[19] LU M, YANG S, HO Y, et al. Shape-controlled synthesis of hybrid nanomaterials via three-dimensional hydrodynamic focusing[J]. Acs Nano, 2014, 8(10):10026-10034.
[20] SQUIRES T M, QUAKE S R. Microfluidics: fluid physics at the nanoliter scale[J]. Rev Mod Phys, 2005, 77(3):977-1026.
[21] NOVOTNY J, FORET F. Fluid manipulation on the micro-scale: basics of fluid behavior in microfluidics[J]. J Sep Sci, 2017, 40(1):383-394.
[22] TSUI J H, LEE W, PUN S H, et al. Microfluidics-assisted in vitro drug screening and carrier production[J]. Adv Drug Deliv Rev, 2013, 65(11-12):1575-1588.
[23] DEMELLO J, DEMELLO A. Microscale reactors: nanoscale products[J]. Lab Chip, 2004, 4(2):11-15.
[24] KIM Y, CHUNG B L, MA M, et al. Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices[J]. Nano Lett, 2012, 12(7):3587-3591.
[25] MAEKI M, SAITO T, SATO Y, et al. A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure[J]. Rsc Adv, 2015, 5(57):46181-46185.
[26] LIU Z, YANG Y, DU Y, et al. Advances in droplet-based microfluidic technology and its applications[J]. Chin J Anal Chem, 2017, 45(2):282-295.
[27] REZVANTALAB S, MORAVEJI M K. Microfluidic assisted synthesis of PLGA drug delivery systems[J]. Rsc Adv, 2019, 9(4):2055-2072.
[28] KARNIK R, GU F, BASTO P, et al. Microfluidic platform for controlled synthesis of polymeric nanoparticles[J]. Nano Lett, 2008, 8(9):2906-2912.
[29] CHIESA E, DORATI R, MODENA T, et al. Multivariate analysis for the optimization of microfluidics-assisted nanoprecipitation method intended for the loading of small hydrophilic drugs into PLGA nanoparticles[J]. Int J Pharm, 2018, 536(1):165-177.
[30] MORIKAWA Y, TAGAMI T, HOSHIKAWA A, et al. The use of an efficient microfluidic mixing system for generating stabilized polymeric nanoparticles for controlled drug release[J]. Biol Pharm Bull, 2018, 41(6):899-907.
[31] ABSTIENS K, GOEPFERICH A M. Microfluidic manufacturing improves polydispersity of multicomponent polymeric nanoparticles[J]. J Drug Deliv Sci Tec, 2019, 49:433-439.
[32] YU M, XU L, TIAN F, et al. Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers[J]. Nat Commun, 2018, 9(1):1-11.
[33] AHMAD Z, SHAH A, SIDDIQ M, et al. Polymeric micelles as drug delivery vehicles[J]. Rsc Adv, 2014, 4(33):17028-17038.
[34] TAN Z, LAN W, LIU Q, et al. Kinetically controlled self-assembly of block copolymers into segmented wormlike micelles in microfluidic chips[J]. Langmuir, 2019, 35(1):141-149.
[35] BAINS A, CAO Y, KLY S, et al. Controlling structure and function of polymeric drug delivery nanoparticles using microfluidics[J]. Mol Pharm, 2017, 14(8):2595-2606.
[36] WANG C, SINTON D, MOFFITT M G. Flow-directed block copolymer micelle morphologies via microfluidic self-assembly[J]. J Am Chem Soc, 2011, 133(46):18853-18864.
[37] XU Z, LU C, RIORDON J, et al. Microfluidic manufacturing of polymeric nanoparticles: comparing flow control of multiscale structure in Single-Phase staggered herringbone and Two-Phase reactors[J]. Langmuir, 2016, 32(48):12781-12789.
[38] CAO Y, SILVERMAN L, LU C, et al. Microfluidic manufacturing of SN-38 Loaded polymer nanoparticles with shear processing control of drug delivery properties[J]. Mol Pharm, 2019, 16(1):96-107.
[39] CHEN R, WULFF J E, MOFFITT M G. Microfluidic processing approach to controlling drug delivery properties of Curcumin-Loaded block copolymer nanoparticles[J]. Mol Pharm, 2018, 15(10):4517-4528.
[40] KANASTY R, DORKIN J R, VEGAS A, et al. Delivery materials for siRNA therapeutics[J]. Nat Mater, 2013, 12(11):967-977.
[41] LIU C, FENG Q, SUN J. Lipid nanovesicles by microfluidics: manipulation, synthesis, and drug delivery[J]. Adv Mater, 2018,31(45):1-8.
[42] DE JESUS VALLE M J, SANCHEZ NAVARRO A. Liposomes prepared in absence of organic solvents:sonication versus lipid film hydration method[J]. Curr Pharm Anal, 2015, 11(2):86-91.
[43] CHARCOSSET C, JUBAN A, VALOUR J, et al. Preparation of liposomes at large scale using the ethanol injection method: effect of scale-up and injection devices[J]. Chem Eng Res Des, 2015, 94:508-515.
[44] JAHN A, VREELAND W N, GAITAN M, et al. Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing[J]. J Am Chem Soc, 2004, 126(9):2674-2675.
[45] LI X J, VALADEZ A V, ZUO P, et al. Microfluidic 3D cell culture: potential application for tissue-based bioassays[J]. Bioanalysis, 2012, 4(12):1509-1525.
[46] BALBINO T A, AOKI N T, GASPERINI A A M, et al. Continuous flow production of cationic liposomes at high lipid concentration in microfluidic devices for gene delivery applications[J]. Chem Eng J, 2013, 226:423-433.
[47] VALENCIA P M, PRIDGEN E M, RHEE M, et al. Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy[J]. Acs Nano, 2013, 7(12):10671-10680.
[48] LI Y, LEE R J, HUANG X, et al. Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery[J]. Nanomed-Nanotechnol, 2017, 13(2):371-381.
[49] FORBES N, HUSSAIN M T, BRIUGLIA M L, et al. Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-line size monitoring[J]. Int J Pharm, 2019, 556:68-81.
[50] WANG F, LI C, CHENG J, et al. Recent advances on inorganic nanoparticle-based cancer therapeutic agents[J]. Int J Environ Res Public Health, 2016, 13(12):1182.
[51] ABOU-HASSAN A, SANDRE O, CABUIL V. Microfluidics in inorganic chemistry[J]. Angew Chem Inter Ed, 2010, 49(36):6268-6286.
[52] FENG Q, SUN J, JIANG X. Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications[J]. Nanoscale, 2016, 8(25):12430-12443.
[53] HE P, GREENWAY G, HASWELL S J. Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers[J]. Chem Eng J, 2011, 167(2-3):694-699.
[54] EDEL J B, FORTT R, DEMELLO J C, et al. Microfluidic routes to the controlled production of nanoparticles[J]. Chem Commun, 2002,(10):1136-1137.
[55] STOLZENBURG P, LORENZ T, DIETZEL A, et al. Microfluidic synthesis of metal oxide nanoparticles via the nonaqueous method[J]. Chem Eng Sci, 2018, 191:500-510.
[56] WEI Z, CHEN Y, LIN P, et al. Synthesis and encapsulation of all inorganic perovskite nanocrystals by microfluidics[J]. J Mater Sci, 2019, 54(9):6841-6852.
[57] JO Y K, LEE D. Biopolymer microparticles prepared by microfluidics for biomedical applications[J]. Small, 2019:1-23.
[58] LOHCHAROENKAL W, WANG L, CHEN Y C, et al. Protein nanoparticles as drug delivery carriers for cancer therapy[J]. Biomed Res Int, 2014,2014:Article ID 180549.
[59] YEWALE C, BARADIA D, VHORA I, et al. Proteins: emerging carrier for delivery of cancer therapeutics[J]. Expert Opin Drug Del, 2013, 10(10):1429-1448.
[60] QU N, SUN Y, LI Y, et al. Docetaxel-loaded human serum albumin (HSA) nanoparticles:synthesis, characterization, and evaluation[J]. Biomed Eng Online, 2019, 18(11):1-14.
[61] SUN Y, ZHAO Y, TENG S, et al. Folic acid receptor-targeted human serum albumin nanoparticle formulation of cabazitaxel for tumor therapy[J]. Int J Nanomed, 2019, 14:135-148.
[62] ZHANG L, CHEN K, ZHANG H, et al. Microfluidic templated multicompartment microgels for 3D encapsulation and pairing of single cells[J]. Small, 2018, 14(9):1-8.
[63] CHOI C, WANG H, LEE H, et al. One-step generation of cell-laden microgels using double emulsion drops with a sacrificial ultra-thin oil shell[J]. Lab Chip, 2016, 16(9):1549-1555.
[64] LIU Q, JIANG N, LIU D, et al. Monodispersed silk fibroin microdroplets for protein stabilization[J]. Appl Phys Lett, 2018, 112(17):1-4.
[65] SAILOR M J, PARK J H. Hybrid nanoparticles for detection and treatment of cancer[J]. Adv Mater, 2012, 24(28):3779-3802.
[66] SHI J, XIAO Z, VOTRUBA A R, et al. Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery[J]. Angew Chem Int Edit, 2011, 50(31):7027-7031.
[67] BOSE R J C, RAVIKUMAR R, KARUPPAGOUNDER V, et al. Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery:advances and challenges[J]. Drug Discov Today, 2017, 22(8):1258-1265.
[68] BOKARE A, TAKAMI A, KIM J H, et al. Herringbone-patterned 3D-printed devices as alternatives to microfluidics for reproducible production of lipid polymer hybrid nanoparticles[J]. ACS Omega, 2019, 4(3):4650-4657.
[69] FENG Q, ZHANG L, LIU C, et al. Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters[J]. Biomicrofluidics, 2015, 9(5):1-10.
[70] ZHANG L, FENG Q, WANG J, et al. Microfluidic synthesis of hybrid nanoparticles with controlled lipid layers:understanding flexibility-regulated cell-nanoparticle interaction[J]. Acs Nano, 2015, 9(10):9912-9921.
[71] HAYES R, AHMED A, EDGE T, et al. Core-shell particles:preparation, fundamentals and applications in high performance liquid chromatography[J]. J Chromatogr A, 2014, 1357:36-52.
[72] CASTILLO S I R, OUHAJJI S, FOKKER S, et al. Silica cubes with tunable coating thickness and porosity:from hematite filled silica boxes to hollow silica bubbles[J]. Micropor Mesopor Mat, 2014, 195:75-86.
[73] MARTINS J P, LIU D, FONTANA F, et al. Microfluidic nanoassembly of bioengineered chitosan-modified FcRn-targeted porous silicon nanoparticles @ hypromellose acetate succinate for oral delivery of antidiabetic peptides[J]. Acs Appl Mater Inter, 2018, 10(51):44354-44367.
[74] FONTANA F, FUSCIELLO M, GROENEVELDT C, et al. Biohybrid vaccines for improved treatment of aggressive melanoma with checkpoint inhibitor[J]. Acs Nano, 2019, 13(6):6477-6490.
[75] KULKARNI J A, TAM Y Y C, CHEN S, et al. Rapid synthesis of lipid nanoparticles containing hydrophobic inorganic nanoparticles[J]. Nanoscale, 2017, 9(36):13600-13609.
[76] VALENCIA P M, BASTO P A, ZHANG L, et al. Single-step assembly of homogenous lipid polymeric and lipid quantum dot nanoparticles enabled by microfluidic rapid mixing[J]. Acs Nano, 2010, 4(3):1671-1679.